Multiwavelength study of 20 jets that emanate from the periphery of active regions

We present a multiwavelength analysis of 20 EUV jets which occurred at the periphery of active regions close to sunspots. We discuss the physical parameters of the jets and their relation with other phenomena such as H alpha surges, nonthermal type III radio bursts and hard X-ray emission. Using AIA wavelength channels sensitive to coronal temperatures, we studied the temperature distribution in the jets using the line-of-sight Differential Emission Measure technique. We also investigated the role of the photospheric magnetic field using the LOS magnetogram data from the HMI. The lifetime of jets range from 5 to 39 minutes with an average of 18 minutes and their velocities range from 87 to 532 km/s with an average of 271 km/s. Most of the jets are co-temporal with nonthermal type III radio bursts observed by the Wind/WAVES spacecraft. We confirm the source region of these bursts using the Potential Field Source Surface technique. 10 out of 20 events showed that the jets originated in a region of flux cancellation and 6 jets in a region of flux emergence. 4 events showed flux emergence and then cancellation during the jet evolution. DEM analyses showed that for most of the spires of the jets, the DEM peaked at around log T [K] = 6.2/6.3. In addition, we derived an emission measure and a lower limit of electron density at the location of the spire and the footpoint. These results are in agreement with those obtained earlier by studying individual active region jets. The observation of flux cancellation, the association with HXR emission and emission of nonthermal type III radio bursts, suggest that the initiation and therefore, heating is taking place at the base of the jet. This is also supported by the high temperature plasma revealed by the DEM analysis in the jet footpoint. Our results provide substantial constraints for theoretical modeling of the jets and their thermodynamic nature.Part of the work was done when one of the authors (SMM) was a Junior Research Fellow at Inter-University Centre of Astronomy and Astrophysics (IUCAA), India. S.M.M. and D.T. acknowledge support from DST under the Fast Track Scheme (SERB/F/3369/2012/2013). S.M.M. also ackowledges support from the Cambridge Trust, University of Cambridge, UK. H.E.M. and G.D.Z. acknowledge the support of STFC. AIA data are courtesy of SDO (NASA) and the AIA consortium. RHESSI work is supported by NASA contract NAS 5-98033. The authors thank the open data policy of WIND/WAVES instrument team. This work utilizes data obtained by the Global Oscillation Network Group (GONG) Program, managed by the National Solar Observatory, which is operated by AURA, Inc. under a cooperative agreement with the National Science Foundation. The data were acquired by instruments operated by the Big Bear Solar Observatory, High Altitude Observatory, Learmonth Solar Observatory, Udaipur Solar Observatory, Instituto de AstrofÃŋsica de Canarias, and Cerro Tololo Interamerican Observatory.This is the final version of the article. It first appeared from EDP Sciences via http://dx.doi.org/10.1051/0004-6361/20152747

Stereotyping starlings are more 'pessimistic'.

Negative affect in humans and animals is known to cause individuals to interpret ambiguous stimuli pessimistically, a phenomenon termed 'cognitive bias'. Here, we used captive European starlings (Sturnus vulgaris) to test the hypothesis that a reduction in environmental conditions, from enriched to non-enriched cages, would engender negative affect, and hence 'pessimistic' biases. We also explored whether individual differences in stereotypic behaviour (repetitive somersaulting) predicted 'pessimism'. Eight birds were trained on a novel conditional discrimination task with differential rewards, in which background shade (light or dark) determined which of two covered dishes contained a food reward. The reward was small when the background was light, but large when the background was dark. We then presented background shades intermediate between those trained to assess the birds' bias to choose the dish associated with the smaller food reward (a 'pessimistic' judgement) when the discriminative stimulus was ambiguous. Contrary to predictions, changes in the level of cage enrichment had no effect on 'pessimism'. However, changes in the latency to choose and probability of expressing a choice suggested that birds learnt rapidly that trials with ambiguous stimuli were unreinforced. Individual differences in performance of stereotypies did predict 'pessimism'. Specifically, birds that somersaulted were more likely to choose the dish associated with the smaller food reward in the presence of the most ambiguous discriminative stimulus. We propose that somersaulting is part of a wider suite of behavioural traits indicative of a stress response to captive conditions that is symptomatic of a negative affective state

Cool and hot emission in a recurring active region jet

Aims. We present a thorough investigation of the cool and hot temperature components in four recurring active region jets observed on July 10, 2015 using the Atmospheric Imaging Assembly (AIA), X-ray Telescope (XRT), and Interface Region Imaging Spectrograph (IRIS) instruments. Methods. A Differential Emission Measure (DEM) analysis was performed on areas in the jet spire and footpoint regions by combining the IRIS spectra and the AIA observations. This procedure better constrains the low temperature DEM values by adding IRIS spectral lines. Plasma parameters, such as doppler velocities, electron densities, nonthermal velocities and a filling factor were also derived from the IRIS spectra. Results. In the DEM analysis, significant cool emission was found in the spire and the footpoint regions. The hot emission was peaked at log T [K] = 5.6-5.9 and 6.5 respectively. The DEM curves show the presence of hot plasma (T = 3 MK) in the footpoint region. We confirmed this result by estimating the Fe XVIII emission from the AIA 94 Å channel which was formed at an effective temperature of log T [K] = 6.5. The average XRT temperatures were also found to be in agreement with log T [K] = 6.5. The emission measure (EM) was found to be three orders of magnitude higher in the AIA-IRIS DEM compared with that obtained using only AIA. The O IV (1399/1401 Å) electron densities were found to be close to those obtained by Cheung et al. (2015). Different threads along the spire show different plane-of-sky velocities both in the lower corona and transition region. Doppler velocities of 32 km/s (blueshifted) and 13 km/s (redshifted) were obtained in the spire and footpoint, respectively from the Si IV 1402.77 Å spectral line. Nonthermal velocities of 69 and 53 km/s were recorded in the spire and footpoint region, respectively. We obtained a filling factor of 0.1 in the spire at log T [K] = 5. Conclusions. The recurrent jet observations confirmed the presence of significant cool emission co-spatial with the coronal emission.SMM acknowledges support from the Cambridge Trust, University of Cambridge, UK. HEM and GDZ acknowledge the support of STFC

Scientists Want More Children

Scholars partly attribute the low number of women in academic science to the impact of the science career on family life. Yet, the picture of how men and women in science – at different points in the career trajectory – compare in their perceptions of this impact is incomplete. In particular, we know little about the perceptions and experiences of junior and senior scientists at top universities, institutions that have a disproportionate influence on science, science policy, and the next generation of scientists. Here we show that having fewer children than wished as a result of the science career affects the life satisfaction of science faculty and indirectly affects career satisfaction, and that young scientists (graduate students and postdoctoral fellows) who have had fewer children than wished are more likely to plan to exit science entirely. We also show that the impact of science on family life is not just a woman's problem; the effect on life satisfaction of having fewer children than desired is more pronounced for male than female faculty, with life satisfaction strongly related to career satisfaction. And, in contrast to other research, gender differences among graduate students and postdoctoral fellows disappear. Family factors impede talented young scientists of both sexes from persisting to research positions in academic science. In an era when the global competitiveness of US science is at risk, it is concerning that a significant proportion of men and women trained in the select few spots available at top US research universities are considering leaving science and that such desires to leave are related to the impact of the science career on family life. Results from our study may inform university family leave policies for science departments as well as mentoring programs in the sciences

Detectability of the degree of freeze damage in meat analytic-tool depends on selection

Novel freezing solutions are constantly being developed to reduce quality loss in meat production chains. However, there is limited focus on identifying the sensitive analytical tools needed to directly validate product changes that result from potential improvements in freezing technology. To benchmark analytical tools relevant to meat research and production, we froze pork samples using traditional (−25 °C, −35 °C) and cryogenic freezing (−196 °C). Three classes of analyses were tested for their capacity to separate different freeze treatments: thaw loss testing, bioelectrical spectroscopy (nuclear magnetic resonance, microwave, bioimpedance) and low-temperature microscopy (cryo-SEM). A general effect of freeze treatment was detected with all bioelectrical methods. Yet, only cryo-SEM resolved quality differences between all freeze treatments, not only between cryogenic and traditional freezing. The detection sensitivity with cryo-SEM may be explained by testing meat directly in the frozen state without prior defrosting. We discuss advantages, shortcomings and cost factors in using analytical tools for quality monitoring in the meat sector

Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1

Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners. However, short synthetic peptides with sequences corresponding to such protein epitopes are unstructured in water and promiscuously bind to proteins with low affinity and specificity. Here we combine structural stability and target specificity of proteins, with low cost and rapid synthesis of small molecules, towards meeting the significant challenge of binding coiled coil proteins in transcriptional regulation. By iteratively truncating a Jun-based peptide from 37 to 22 residues, strategically incorporating i-->i+4 helix-inducing constraints, and positioning unnatural amino acids, we have produced short, water-stable, alpha-helical peptides that bind cFos. A three-dimensional NMR-derived structure for one peptide (24) confirmed a highly stable alpha-helix which was resistant to proteolytic degradation in serum. These short structured peptides are entropically pre-organized for binding with high affinity and specificity to cFos, a key component of the oncogenic transcriptional regulator Activator Protein-1 (AP-1). They competitively antagonized the cJun–cFos coiled-coil interaction. Truncating a Jun-based peptide from 37 to 22 residues decreased the binding enthalpy for cJun by ~9 kcal/mol, but this was compensated by increased conformational entropy (TDS ≤ 7.5 kcal/mol). This study demonstrates that rational design of short peptides constrained by alpha-helical cyclic pentapeptide modules is able to retain parental high helicity, as well as high affinity and specificity for cFos. These are important steps towards small antagonists of the cJun-cFos interaction that mediates gene transcription in cancer and inflammatory diseases

Slipping magnetic reconnection, chromospheric evaporation, implosion, and precursors in the 2014 September 10 X1.6-class solar flare

© 2016. The American Astronomical Society. All rights reserved.. We investigate the occurrence of slipping magnetic reconnection, chromospheric evaporation, and coronal loop dynamics in the 2014 September 10 X-class flare. Slipping reconnection is found to be present throughout the flare from its early phase. Flare loops are seen to slip in opposite directions toward both ends of the ribbons. Velocities of 20-40 km s-1 are found within time windows where the slipping is well resolved. The warm coronal loops exhibit expanding and contracting motions that are interpreted as displacements due to the growing flux rope that subsequently erupts. This flux rope existed and erupted before the onset of apparent coronal implosion. This indicates that the energy release proceeds by slipping reconnection and not via coronal implosion. The slipping reconnection leads to changes in the geometry of the observed structures at the Interface Region Imaging Spectrograph slit position, from flare loop top to the footpoints in the ribbons. This results in variations of the observed velocities of chromospheric evaporation in the early flare phase. Finally, it is found that the precursor signatures, including localized EUV brightenings as well as nonthermal X-ray emission, are signatures of the flare itself, progressing from the early phase toward the impulsive phase, with the tether-cutting being provided by the slipping reconnection. The dynamics of both the flare and outlying coronal loops is found to be consistent with the predictions of the standard solar flare model in three dimensions

Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid

BACKGROUND: Staphylococcal infection of the canine epidermis and hair follicle is amongst the commonest reasons for antimicrobial prescribing in small animal veterinary practice. Topical therapy with fusidic acid (FA) is an attractive alternative to systemic therapy based on low minimum inhibitory concentrations (MICs, commonly <0.03 mg/l) documented in canine pathogenic staphylococci, including strains of MRSA and MRSP (methicillin-resistant Staphylococcus aureus and S. pseudintermedius). However, permeation of canine skin by FA has not been evaluated in detail. This study aimed to define the degree and extent of FA permeation in canine skin in vitro from two sites with different hair follicle density following application of a licensed ophthalmic formulation that shares the same vehicle as an FA-betamethasone combination product approved for dermal application in dogs. Topical FA application was modelled using skin held in Franz-type diffusion cells. Concentrations of FA in surface swabs, receptor fluid, and transverse skin sections of defined anatomical depth were determined using high-performance liquid chromatography and ultraviolet (HPLC-UV) analysis. RESULTS: The majority of FA was recovered by surface swabs after 24 h, as expected (mean ± SEM: 76.0 ± 17.0%). FA was detected within 424/470 (90%) groups of serial sections of transversely cryotomed skin containing follicular infundibula, but never in 48/48 (100%) groups of sections containing only deeper follicular structures, nor in receptor fluid, suggesting that FA does not permeate beyond the infundibulum. The FA concentration (mean ± SEM) in the most superficial 240 μm of skin was 2000 ± 815 μg/g. CONCLUSIONS: Topically applied FA can greatly exceed MICs for canine pathogenic staphylococci at the most common sites of infection. Topical FA therapy should now be evaluated using available formulations in vivo as an alternative to systemic therapy for canine superficial bacterial folliculitis.Peer reviewedFinal Published versio

Nonequilibrium Singlet-Triplet Kondo Effect in Carbon Nanotubes

The Kondo-effect is a many-body phenomenon arising due to conduction electrons scattering off a localized spin. Coherent spin-flip scattering off such a quantum impurity correlates the conduction electrons and at low temperature this leads to a zero-bias conductance anomaly. This has become a common signature in bias-spectroscopy of single-electron transistors, observed in GaAs quantum dots as well as in various single-molecule transistors. While the zero-bias Kondo effect is well established it remains uncertain to what extent Kondo correlations persist in non-equilibrium situations where inelastic processes induce decoherence. Here we report on a pronounced conductance peak observed at finite bias-voltage in a carbon nanotube quantum dot in the spin singlet ground state. We explain this finite-bias conductance anomaly by a nonequilibrium Kondo-effect involving excitations into a spin triplet state. Excellent agreement between calculated and measured nonlinear conductance is obtained, thus strongly supporting the correlated nature of this nonequilibrium resonance.Comment: 21 pages, 5 figure